Can you have too much weight on the wheels?

My rims and tyres weigh just under 200gs and am adding about 80gs for the total 280gs per wheel. Im not planning to add any other weight i.e. portal covers etc. These are going on a TRX4 sport with a Holmes Hobby motor either a 27 or 45 T 550 size . Standard spur and 15t pinion with the hobbywing 1080 ESC.